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Contezolid

Chemical Structure : Contezolid

CAS No.: 1112968-42-9

Contezolid (MRX I)

Catalog No.: PC-61371Not For Human Use, Lab Use Only.

Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL.

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    Biological Activity

    Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL; demonstrates the same or better efficacy than linezolid in both systemic and local infection models against the tested strains.

    Bacterial Infection

    Phase 3 Clinical

    Physicochemical Properties

    M.Wt 408.337
    Formula C18H15F3N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-{2,3,6-trifluoro-4-[(5S)-5-{[(1,2-oxazol-3-yl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}-2,3-dihydropyridin-4(1H)-one

    References

    1. Li CR, et al. Antimicrob Agents Chemother. 2014;58(4):2418-21.

    2. Gordeev MF, et al. J Med Chem. 2014 Jun 12;57(11):4487-97.

    3. Meng J, et al. Drug Metab Dispos. 2015 May;43(5):646-59.

    4. Eckburg PB, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02181-16.

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