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Chemical Structure : Copanlisib
CAS No.: 1032568-63-0
Catalog No.: PC-20534Not For Human Use, Lab Use Only.
Copanlisib (BAY 80-6946) is a potent, highly selective pan-class I PI3K inhibitor with IC50 of 0.5, 3.7, 6.4, and 0.7 nM for PI3Kα, β, γ, and δ isoforms, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | $728 | In stock | |
| 1 g | Get quote |
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Copanlisib (BAY 80-6946) is a potent, highly selective pan-class I PI3K inhibitor with IC50 of 0.5, 3.7, 6.4, and 0.7 nM for PI3Kα, β, γ, and δ isoforms, respectively.
BAY 80-6946 shows significantly weaker activity against mTOR with an IC50 of 45 nM, does not inhibit PI4K-II, PIP4-5K, PIP5-4K, or an additional 220 kinases in the Millipore kinase panel (inhibition <30%) at 1 uM.
BAY 80-6946 reduces basal levels of AKT phosphorylation at both Thr308 and Ser473 with IC50 values of 0.4 and 0.6 nmol/L, respectively, in KPL4 cells.
BAY 80-6946 is a potent inhibitor of tumor cell proliferation and shows activity in a subset of human cancer cell lines with PIK3CA mutations and/or overexpression of HER2.
BAY 80-6946 induces apoptosis in a subset of tumor cell lines that are resistant to lapatinib and trastuzumab.
BAY 80-6946 is highly efficacious in rat and mouse tumor xenograft models following intravenous administration.
| M.Wt | 480.53 | |
| Formula | C23H28N8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=C(C1=CN=C(N)N=C1)NC2=NC3=C(C=CC(OCCCN4CCOCC4)=C3OC)C5=NCCN25 |
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1. Liu N, et al. Mol Cancer Ther. 2013 Nov;12(11):2319-30.
2. Will M, et al. Cancer Discov. 2014 Mar;4(3):334-47.
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