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Chemical Structure : Cortistatin A
Catalog No.: PC-60894Not For Human Use, Lab Use Only.
A potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19.
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A potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19; does not inhibit other transcriptional CDKs CDK7 (TFIIH), CDK9 (P-TEFb), CDK12, or CDK13 in vitro, and no activity against CDK9, CDK12, CDK13, ROCK1 or ROCK2 in MOLM-14 cell lysate (>2.5 uM), also binds to ROCK1 and ROCK2; demonstrates antileukaemic activity by inhibiting Mediator kinases in vitro and in vivo.
| M.Wt | 472.629 | |
| Formula | C30H36N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108.
2. Cee VJ, et al. Angew Chem Int Ed Engl. 2009;48(47):8952-7.
3. Poss ZC, et al. Cell Rep. 2016 Apr 12;15(2):436-50.
4. Pelish HE, et al. Nature. 2015 Oct 8;526(7572):273-276.
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