You are here:Home-Chemical Inhibitors & Agonists-GPCR-Glucagon Receptor-Cotadutide acetate
Cotadutide acetate

Chemical Structure : Cotadutide acetate

CAS No.: 1903768-17-1

Cotadutide acetate (MEDI0382 acetate)

Catalog No.: PC-72602Not For Human Use, Lab Use Only.

Cotadutide acetate (MEDI-0382, MEDI0382) is a potent dual GLP-1/glucagon receptor peptide agonist with EC50 values of 6.9 pM and 10.2 pM, respectively.

Packing Price Stock Quantity
5 mg $458 In stock
10 mg $728 In stock
25 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cotadutide acetate (MEDI-0382, MEDI0382) is a potent dual GLP-1/glucagon receptor peptide agonist with EC50 values of 6.9 pM and 10.2 pM, respectively.
Cotadutide (MEDI-0382, MEDI0382) stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC50: 226 pM and 1051 pM, respectively ), as well as rat, mouse and human hepatocytes (EC50: 462 pM, 840 pM, 1447 pM, respectively).
Cotadutide (MEDI-0382, MEDI0382) potentiates glucose-stimulated insulin secretion in the rat (INS-1 832/3) pancreatic β‐cell line and increases glucose output in rat hepatocytes.
Cotadutide (MEDI-0382, MEDI0382) induces mitochondrial turnover and enhances mitochondrial function in mouse primary hepatocytes.
Cotadutide (MEDI-0382, MEDI0382) (10- 30 nmol/kg, s.c.) suppresses food intake and reduces body weight in DIO mice, reduces hepatic fibrosis and inflammation in in ob/ob AMLN NASH mice.

Physicochemical Properties

M.Wt 3788.14
Formula C169H256N42O57
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,4R)-1-{[3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol1-yl]acetyl}-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine2-carboxamide

References

1. Henderson SJ, et al. Diabetes Obes Metab. 2016 Dec;18(12):1176-1190.

2. Ambery PD, et al. Br J Clin Pharmacol. 2018 Oct;84(10):2325-2335.

3. Ambery P, et al. Lancet. 2018 Jun 30;391(10140):2607-2618.

4. Boland ML, et al. Nat Metab. 2020 May;2(5):413-431.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: