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Curcumin

Chemical Structure : Curcumin

CAS No.:

Curcumin (Diferuloylmethane, Natural Yellow 3)

Catalog No.: PC-24370Not For Human Use, Lab Use Only.

Curcumin (Diferuloylmethane) is a specific p300/CREB-binding protein acetyltransferase, inhibits acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Curcumin (Diferuloylmethane) is a specific p300/CREB-binding protein acetyltransferase, inhibits acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.
Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities.
Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

Physicochemical Properties

M.Wt 368.39
Formula C21H20O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

References

1. Zhu X, et al. PLoS One. 2014 Mar 6;9(3):e91303.

2. Balasubramanyam K, et al. J Biol Chem. 2004 Dec 3;279(49):51163-71.

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