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Chemical Structure : Cyanotriazole CT3
Catalog No.: PC-20947Not For Human Use, Lab Use Only.
Cyanotriazole CT3 is a potent, selective, irreversible inhibitor of trypanosomal topoisomerase II, shows potent trypanocidal activity both in vitro and in vivo.
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Cyanotriazole CT3 is a potent, selective, irreversible inhibitor of trypanosomal topoisomerase II, shows potent trypanocidal activity both in vitro and in vivo.
Cyanotriazole CT3 is a potent growth inhibitor of a panel of kinetoplastid parasites, which includes T. cruzi and L. donovani (EC50, 78 and 134 nM), but has no activity against a range of nontrypanosomatid microbial pathogens.
Cyanotriazole CT3 (30 mg/kg) is efficacious against trypanosomatid parasites in vivo.
Cyanotriazole CT3-treated parasites showes defects in nuclear DNA replication, exhibited up-regulated DNA damage response.
Cyanotriazole CT3 selectively inhibits the DNA relaxation activity of trypanosome TopoII by stabilizing the dsDNA:enzyme complex, interacts covalently with C477 and bind at the DNA cleavage site.
| M.Wt | 416.34 | |
| Formula | C19H12F4N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Srinivasa P S Rao, et al. Science. 2023 Jun 30;380(6652):1349-1356.
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