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Cyclapolin 1

Chemical Structure : Cyclapolin 1

CAS No.: 736157-02-1

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Cyclapolin 1

Catalog No.: PC-62159Not For Human Use, Lab Use Only.

Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases.
    Cyclapolin 1 treatment leads to collapsed spindles in living cells, in contrast to the metaphase-arrested bipolar spindles observed after RNAi.

    Physicochemical Properties

    M.Wt 339.263
    Formula C9H4F3N3O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-carbamoyl-7-nitro-5-((trifluoromethyl)thio)benzo[d]thiazole 3-oxide

    References

    1. McInnes C, et al. Nat Chem Biol. 2006 Nov;2(11):608-17.

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