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Chemical Structure : Cyclapolin 1
Catalog No.: PC-62159Not For Human Use, Lab Use Only.
Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases.
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Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases.
Cyclapolin 1 treatment leads to collapsed spindles in living cells, in contrast to the metaphase-arrested bipolar spindles observed after RNAi.
| M.Wt | 339.263 | |
| Formula | C9H4F3N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McInnes C, et al. Nat Chem Biol. 2006 Nov;2(11):608-17.
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