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Chemical Structure : Cyclin K degrader DS17
CAS No.:
Catalog No.: PC-21140Not For Human Use, Lab Use Only.
Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM.
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Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 13 nM.
Cyclin K degrader DS17 is more effective at depleting cyclin K than CR8 at 1 µM concentration.
Cyclin K degrader DS17 acquires glue activity via simultaneous CDK12 binding and engagement of DDB1 interfacial residues, in particular Arg928.
| M.Wt | 435.31 | |
| Formula | C18H20Cl2N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-((6-(((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-methyl-9H-purin-2-yl)amino)butan-1-ol |
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1. Zuzanna Kozicka, et al. Nat Chem Biol. 2023 Sep 7. doi: 10.1038/s41589-023-01409-z.
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