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Chemical Structure : D-4-77
Catalog No.: PC-21119Not For Human Use, Lab Use Only.
D-4-77 is a potent, covalent peptidyl inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 0.95 uM and antiviral EC50 of 0.49 uM.
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D-4-77 is a potent, covalent peptidyl inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 0.95 uM and antiviral EC50 of 0.49 uM.
D-4-77 binds to the S1'-S3' pocket and revealed a covalent mechanism.
D-4-77 functions as an immune protectant and suppresses SARS-CoV-2 Mpro-induced antagonism of the host NF-κB innate immune response.
| M.Wt | 512.45 | |
| Formula | C23H34BrN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ming Liu, et al. Angew Chem Int Ed Engl. 2023 Aug 23;e202309657.
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