Chemical Structure : D-583
CAS No.:
2086258-61-7
D-583
(D583)
Catalog No.: PC-25355Not For Human Use, Lab Use Only.
D-583 is a potent hybrid D2/D3 agonist and iron (II)-specific chelator with EC50 of 3.14 nM (Emax=63%) and 0.62 nM (Emax=68%) for D2 and D3 receptors respectively, exhibits anti-ferroptotic activity.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
D-583 is a potent hybrid D2/D3 agonist and iron (II)-specific chelator with EC50 of 3.14 nM (Emax=63%) and 0.62 nM (Emax=68%) for D2 and D3 receptors respectively, exhibits anti-ferroptotic activity.
D-583 (0.1-20 uM) significantly protect PC12 cells from the toxic effects of 6-OHDA.
D-583 (0.1-20 uM) dose dependently protect PANC-1 cells from the toxicity of RSL3.
D-583 (1 uM, 10 uM) induces dose dependent reduction of ROS in PANC1 cells.
D-583 dose dependently restored ferroptosis marker proteins GPX4, SLC7A11 and Nrf2.
D-583 (5 µMol/kg)s ignificantly reversed akinesia in Parkinson's disease animal model.
Physicochemical Properties
|
M.Wt
|
471.65
|
|
Formula
|
C29H37N5O
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-6-((2-(4-([2,2'-bipyridin]-5-yl)piperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol
|
References
1. Vibha Deshpande, et al. Neurochem Res. 2025 Aug 13;50(4):264.
Contact Us
sales@probechem.com
