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Chemical Structure : D089
CAS No.: 880440-91-5
Catalog No.: PC-47053Not For Human Use, Lab Use Only.
D089 is a selective small molecule stabilizer of the MYC G4-quadruplex, not only inhibits MYC expression in myeloma cell lines, but also selectively induces G1 arrest in MYC-driven cancer cell lines containing the MYC-G4 sequence.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $548 | In stock | |
| 50 mg | $898 | In stock | |
| 100 mg | Get quote |
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D089 is a selective small molecule stabilizer of the MYC G4-quadruplex, not only inhibits MYC expression in myeloma cell lines, but also selectively induces G1 arrest in MYC-driven cancer cell lines containing the MYC-G4 sequence.
D089 reduces MYC transcription and induces cytotoxicity in myeloma cells (L363 MM cells, IC50=13 uM).
D089 induces the canonical pathways involved in the unfolded protein response, endoplasmic reticulum stress, and inflammatory responses to modulate cell cycle progression, senescence and caspase 1-mediated cell death by pyroptosis.
D089 kills cells independent of effector caspase 3 (CASP3), induces caspase-1 and 8 dependent cell death mechanism (pyroptosis).
| M.Wt | 392.499 | |
| Formula | C24H28N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(azepan-1-ylmethyl)-5-hydroxy-2-methyl-N-(p-tolyl)benzofuran-3-carboxamide |
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1. Snehal M Gaikwad, et al. Cancers (Basel). 2020 Oct 13;12(10):2952.
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