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D13-9001

Chemical Structure : D13-9001

CAS No.: 957471-96-4

D13-9001 (D 13-9001)

Catalog No.: PC-35872Not For Human Use, Lab Use Only.

D13-9001 (D 13-9001) is a small molecule, MexAB-OprM specific efflux pump inhibitor with good potency in vitro (MPC 2 ug/mL) and displays excellent activity in vivo in a rat pneumonia model of P. aeruginosa..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

D13-9001 (D 13-9001) is a small molecule, MexAB-OprM specific efflux pump inhibitor with good potency in vitro (MPC 2 ug/mL) and displays excellent activity in vivo in a rat pneumonia model of P. aeruginosa.

Physicochemical Properties

M.Wt 1386.604
Formula C63H81N22O11S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethanaminium, N-(carboxymethyl)-2-[[[[(3R)-1-[8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carbonyl]-4-oxo-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl]-3-piperidinyl]oxy]carbonyl]amino]-N,N-dimethyl-, inner salt

References

1. Ranjitkar S, et al. Antimicrob Agents Chemother. 2018 Nov 12. pii: AAC.01718-18. doi: 10.1128/AAC.01718-18.

2. Yoshida K, et al. Bioorg Med Chem. 2007 Nov 15;15(22):7087-97.

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