Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : D4476
CAS No.: 301836-43-1
Catalog No.: PC-42523Not For Human Use, Lab Use Only.
D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro.
D4476 slightly weaker for ALK5 inhibition (IC50=0.5 uM); weak activity for p38α MAPK and no activity for PKB, SGK.
D4476 specifically inhibits the phosphorylation of endogenous FOXO1a on Ser322 and Ser325.
D4476 more potent and specific than IC261 or CKI-7.
| M.Wt | 398.414 | |
| Formula | C23H18N4O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzamide, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]- |
|
1. Rena G, et al. EMBO Rep. 2004 Jan;5(1):60-5.
2. Bryja V, et al. Cell Signal. 2007 Mar;19(3):610-6.
3. Huart AS, et al. J Biol Chem. 2009 Nov 20;284(47):32384-94.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
