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Chemical Structure : DBIBB
CAS No.: 1569309-92-7
Catalog No.: PC-60889Not For Human Use, Lab Use Only.
DBIBB is a potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $578 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DBIBB is a potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors.
DBIBB displays 33-fold increased potency over GRI977143.
DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation and reduces apoptosis.
DBIBB enhances DNA repair by augmenting the resolution of γ-H2AX foci, increases clonogenic survival of irradiated IEC-6 cells, attenuates the radiation-induced death of human CD34(+) hematopoietic progenitors and enhances the survival of the granulocyte/macrophage lineage in mice.
| M.Wt | 452.5 | |
| Formula | C23H20N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-benzoic acid |
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1. Patil R, et al. Chem Biol. 2015 Feb 19;22(2):206-16.
2. Knowlden SA, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):402-9.
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