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Chemical Structure : DD-01050
Catalog No.: PC-60720Not For Human Use, Lab Use Only.
DD-01050 is a potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity.
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DD-01050 is a potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity.
DD-01050 preferentially inhibits TRPV1, showing marginal block of other neuronal receptors.
DD-01050 inhibits capsaicin-evoked nerve activity in afferent fibers without affecting mechanically activated activity, attenuates carrageenan-induced paw inflammation, without affecting normal nociception in vivo.
DD-01050 also decreases the cells in S/G2/M phases in prostate PC3 cells.
| M.Wt | 633.396 | |
| Formula | C26H33Cl4N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. García-Martínez C, et al. J Pain. 2006 Oct;7(10):735-46.
2. Valero ML, et al. PLoS One. 2012;7(12):e51825.
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