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DDD01510706

Chemical Structure : DDD01510706

CAS No.: 2170696-76-9

DDD01510706

Catalog No.: PC-49292Not For Human Use, Lab Use Only.

DDD01510706 is a small molecule inhibitor of PfKRS (Plasmodium falciparum Lysyl tRNA Synthetase) with pIC50 of 6.62, interacts with the ATP binding site of PfKRS, inhibits plasmodium falciparum asexual blood-stage (ABS) parasite strain Dd2 with EC50 of 0.3 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DDD01510706 is a small molecule inhibitor of PfKRS (Plasmodium falciparum Lysyl tRNA Synthetase) with pIC50 of 6.62, interacts with the ATP binding site of PfKRS, inhibits plasmodium falciparum asexual blood-stage (ABS) parasite strain Dd2 with EC50 of 0.3 uM.

Physicochemical Properties

M.Wt 355.313
Formula C17H16F3NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-6-fluoro-4-oxo-4H-chromene-2-carboxamide

References

1. Rachel Milne, et al. ACS Infect. Dis. 2022.

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