Chemical Structure : DDO-7432
CAS No.:
DDO-7432
(DDO7432)
Catalog No.: PC-27714Not For Human Use, Lab Use Only.
DDO-7432 is a specific, orally bioavailable molecular glue that induces aberrant STING oligomerization, inhibits STING activity with IC50 of 1.37 uM in IRF luciferase reporter assays in THP-1-Dual cells, induces self-association of STING to inhibit STING-dependent signal transduction.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DDO-7432 is a specific, orally bioavailable molecular glue that induces aberrant STING oligomerization, inhibits STING activity with IC50 of 1.37 uM in IRF luciferase reporter assays in THP-1-Dual cells, induces self-association of STING to inhibit STING-dependent signal transduction.
DDO-7432 suppresses the inflammatory response induced by HSV-1 infection in THP-1 cells.
DDO-7432 (60 mg/kg administered intragastrically) partially suppressed IFN-β secretion in serum and downregulated the expression of Mx1 and Cxcl10 in C57BL/6JSTING-Hu mice.
DDO-7432 (30 or 60 mg/kg, oral gavage) significantly reduced ISGs expression and attenuated inflammatory parameters in muscle tissue from C57BL/6JSTING-Hu myositis model.
Physicochemical Properties
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M.Wt
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434.15
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Formula
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C17H8Cl2F3NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-chloro-3-(3-chloro-4-(trifluoromethoxy)benzamido)benzofuran-2-carboxylic acid
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References
1. Zi-Wen Feng, et al. Signal Transduct Target Ther. 2026 Aug 4;11(1):308.
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