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Chemical Structure : DDX3-IN-16d
Catalog No.: PC-70309Not For Human Use, Lab Use Only.
A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3), a human host factor required for the replication of several DNA and RNA viruses.
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A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3), a human host factor required for the replication of several DNA and RNA viruses; shows a broad spectrum of antiviral activity with EC50 of 0.97-16.5 uM (HIV, HCV, DENV, and WNV), retaines full activity against HIV drug-resistant strains (EC50<1 uM); exhibts a good safety profile and bioavailability in rats.
| M.Wt | 307.357 | |
| Formula | C17H17N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brai A, et al. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5388-93.
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