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Chemical Structure : DF2593A
Catalog No.: PC-38339Not For Human Use, Lab Use Only.
DF2593A (DF 2593A) is a potent, selective, noncompetitive allosteric inhibitor of C5aR with IC50 of 5 nM (C5a-induced human PMN migration inhibition), and rat and mouse orthologs (IC50=6.0 nM and IC50=1.0 nM, respectively).
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DF2593A (DF 2593A) is a potent, selective, noncompetitive allosteric inhibitor of C5aR with IC50 of 5 nM (C5a-induced human PMN migration inhibition), and rat and mouse orthologs (IC50=6.0 nM and IC50=1.0 nM, respectively).
DF2593A dispalys >1,000-fold selective versus other chemoattractants, including CXCL8 and CXCL1 (CI50>10 uM), as well as on a panel of different GPCRs and ion channels.
DF2593A demonstrated antinociceptive effects in several models of inflammatory pain and effectively inhibited articular hyperalgesia in CFA-induced mechanical and thermal hyperalgesia and arthritic nociception.
| M.Wt | 458.921 | |
| Formula | C18H26ClF3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (4.9 mg/mL) |
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1. Moriconi A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16937-42.
2. D'Angelo R, et al. Biomed Pharmacother. 2020 Mar;123:109764.
3. Li XX, et al. Biochem Pharmacol. 2020 Oct;180:114156.
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