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Chemical Structure : DFL 23448
Catalog No.: PC-60742Not For Human Use, Lab Use Only.
A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold.
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A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats.
| M.Wt | 291.304 | |
| Formula | C12H10FN5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mistretta FA, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):200-11.
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