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Chemical Structure : DFMTI
CAS No.: 864864-86-8
Catalog No.: PC-42136Not For Human Use, Lab Use Only.
A potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively; display liitle to no activity for mGluR5, mGluR2 and mGluR8; has improved in vivo DMPK profiles and shows antipsychotic-like effect at a dose of 1 mg/kg in an animal model.
| M.Wt | 368.3799 | |
| Formula | C20H18F2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Isoindol-1-one, 5-[1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-2-(1-methylethyl)- |
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1. Ito S, et al. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5310-3.
2. Cho HP, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.
3. Satoh A, et al. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5464-8.
4. Hostetler E, et al. Synapse. 2011 Feb;65(2):125-35.
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