DFP-4AP

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Chemical Structure : DFP-4AP

Catalog No.: PC-28492Not For Human Use, Lab Use Only.

DFP-4AP is a small molecule inhibitor of HIV-1 accessory protein Nef, inhibits the Nef-Hck complex via the Hck kinase domain, inhibits Nef-induced Hck activation (IC50=5.1 uM) and HIV-1 replication (IC50=6 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DFP-4AP is a small molecule inhibitor of HIV-1 accessory protein Nef, inhibits the Nef-Hck complex via the Hck kinase domain, inhibits Nef-induced Hck activation (IC50=5.1 uM) and HIV-1 replication (IC50=6 uM).

Physicochemical Properties

M.Wt	345.40
Formula	C21H19N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)amino]-1-propanol

References

1. Ryan P Staudt, et al. J Biol Chem. 2020 Oct 30;295(44):15158-15171.

2. Lori Emert-Sedlak, et al. ACS Chem Biol. 2009 Nov 20;4(11):939-47.

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DFP-4AP

Biological Activity

Physicochemical Properties

References

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