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Chemical Structure : DG-172 dihydrochloride
CAS No.: 1361504-77-9
Catalog No.: PC-45697Not For Human Use, Lab Use Only.
DG-172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $80 | In stock | |
| 50 mg | $312 | In stock | |
| 100 mg | $536 | In stock |
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DG-172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties; inhibits agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor recruitment; down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50= 9.5 nM); orally bioactive.
| M.Wt | 455.2188 | |
| Formula | C20H22BrCl2N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzeneacetonitrile, 2-bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]-, hydrochloride (1:2), (αZ)- |
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1. Lieber S, et al. J Med Chem. 2012 Mar 22;55(6):2858-68.
2. Lieber S, et al. Mol Pharmacol. 2015 Feb;87(2):162-73.
3. Adhikary T, et al. Oncogene. 2013 Oct 31;32(44):5241-52.
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