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Chemical Structure : DGAT1-IN-4
CAS No.: 942999-61-3
Catalog No.: PC-45835Not For Human Use, Lab Use Only.
A potent, selective, and orally efficacious inhibitor of DGAT-1 with IC50 of 15 nM and 9 nM for hDGAT-1 and mDGAT-1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $246.4 | In stock | |
| 50 mg | $740 | In stock |
Bulk size, bulk discount!
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A potent, selective, and orally efficacious inhibitor of DGAT-1 with IC50 of 15 nM and 9 nM for hDGAT-1 and mDGAT-1, respectively; shows no significant activity for ACAT-1 (IC50=5.2 uM); shows effectivity in both intestinal and adipose tissue, reduces body weight or body weight gain following oral administration in both mouse and rat models of dietary-induced obesity.
Obesity
Preclinical
| M.Wt | 420.5041 | |
| Formula | C24H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Bicyclo[2.2.2]octane-1-acetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]- |
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1. Birch AM, et al. J Med Chem. 2009 Mar 26;52(6):1558-68.
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