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Chemical Structure : DHMEQ
CAS No.: 287194-40-5
Catalog No.: PC-47044Not For Human Use, Lab Use Only.
DHMEQ (dehydroxymethylepoxyquinomicin) is an NF-κB inhibitor, inhibits TNF-α-induced activation of NF-κB, and inhibits the TNF-α-induced nuclear accumulation of p65, a component of NF-κB.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | Get quote |
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DHMEQ (dehydroxymethylepoxyquinomicin) is an NF-κB inhibitor, inhibits TNF-α-induced activation of NF-κB, and inhibits the TNF-α-induced nuclear accumulation of p65, a component of NF-κB.
DHMEQ also inhibited TNF-α-induced nuclear transport of green fluorescent protein-tagged p65.
DHMEQ was effective in suppressing rheumatoid arthritis in an in vivo model.
DHMEQ completely inhibited NFkappaB DNA binding activity in JCA-1 cells.
DHMEQ significantly inhibited pre-established JCA-1 s.c. tumor growth in nude mice without any side effects.
| M.Wt | 261.23 | |
| Formula | C13H11NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide |
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1. Ariga A, et al. J Biol Chem. 2002 Jul 5;277(27):24625-30.
2. Chaicharoenpong C, et al. Bioorg Med Chem. 2002 Dec;10(12):3933-9.
3. Kikuchi E, et al. Cancer Res. 2003 Jan 1;63(1):107-10.
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