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Chemical Structure : DIMATE
Catalog No.: PC-61351Not For Human Use, Lab Use Only.
DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor, displays cytotoxic activity on human AML cell lines with IC50 of 1-15 uM.
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DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor, displays cytotoxic activity on human AML cell lines with IC50 of 1-15 uM.
DIMATE shows selective cytotoxicity in leukemic population enriched in LSCs, with no cytotoxicity for healthy hematopoietic stem cells.
DIMATE promotes the accumulation of apoptogenic aldehydes leading to apoptosis and tumor growth inhibition in xenograft mouse models.
| M.Wt | 185.285 | |
| Formula | C9H15NOS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pérez-Alea M, et al. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.160.
2. Venton, et al. Blood Cancer J. 2016 Sep 9;6(9):e469.
3. Quash G, et al. Eur J Med Chem. 2008 May;43(5):906-16.
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