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Chemical Structure : DJ4
Catalog No.: PC-35150Not For Human Use, Lab Use Only.
DJ4 (ROCK inhibitor DJ4) is a potent, selective, ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM, respectively.
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DJ4 (ROCK inhibitor DJ4) is a potent, selective, ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM, respectively.
DJ4 minimally inhibits PAK1 and DMPK, inhibits the phosphorylation of recombinant MYPT1(Thr696) by recombinant ROCK1 and ROCK2.
DJ4 significantly blocks stress fiber formation and inhibits migration and invasion of multiple cancer cell lines in a concentration dependent manner, which is independent of cell death.
| M.Wt | 350.44 | |
| Formula | C19H18N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kale VP, et al. Cancer Lett. 2014 Nov 28;354(2):299-310.
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