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Chemical Structure : DKR-1051
Catalog No.: PC-61102Not For Human Use, Lab Use Only.
DKR-1051 is a novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM).
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DKR-1051 is a novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM).
DKR-1051 modulates intracellular Ca2+ levels in human SK-N-SH neuroblastoma cells。
DKR-1051 relieves spared nerve injury-induced mechanical hypersensitivity in vivo.
| M.Wt | 385.474 | |
| Formula | C24H26F3N | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yi B, et al. J Neurochem. 2017 Feb;140(4):561-575.
2. Sahn JJ, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811.
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