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Chemical Structure : DMH-1
CAS No.: 1206711-16-1
Catalog No.: PC-42935Not For Human Use, Lab Use Only.
DMH1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor with IC50 of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $155 | In stock | |
| 50 mg | $265 | In stock | |
| 100 mg | $485 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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DMH1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor with IC50 of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively; significantly reduces the percentage of cells expressing the pluripotency marker proteins OCT4 and Nanog in both SM3 and CA6 cells, induces regulation of pluripotency and neural precursor marker mRNAs; reduces the canonical phosphorylation of Smads 1,5 and 9, inhibits HeLa and MCF-7 cell proliferation; significantly reduces the tumor growth in human lung cancer xenograft model.
| M.Wt | 380.4418 | |
| Formula | C24H20N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 11.5 mg/mL |
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| Chemical Name/SMILES |
Quinoline, 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- |
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1. Hao J, et al. ACS Chem Biol. 2010 Feb 19;5(2):245-53.
2. Cross EE, et al. ACS Chem Biol. 2011 Sep 16;6(9):952-61.
3. Hao J, et al. PLoS One. 2014 Mar 6;9(6):e90748.
4. Engers DW, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
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