DMJ-I-228 |CAS:1374035-59-2 Probechem Biochemicals

Chemical Structure : DMJ-I-228

Catalog No.: PC-70320Not For Human Use, Lab Use Only.

A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM.

M.Wt	435.84
Formula	C19H19ClFN5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(4-chloro-3-fluorophenyl)-N2-((1S,2S)-2-guanidino-2,3-dihydro-1H-inden-1-yl)oxalamide formate

1. Madani N, et al. Structure. 2008 Nov 12; 16(11):1689-701.

2. Richard J, et al. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2687-94.

3. LaLonde JM, et al. J Med Chem. 2012 May 10;55(9):4382-96.