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Chemical Structure : DNA gyrase inhibitor EN-7
Catalog No.: PC-73116Not For Human Use, Lab Use Only.
DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.
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DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.
EN-7 inhibited growth of the wild-type strain (S. aureus) with MIC 1 μM.
Strains containing GyrA A34T (mut-3 and mut-9), GyrA P219Q (mut-6), and GyrB K417E (mut-1, mut-2, mut-4, and mut-5) exhibited moderate resistance, with MICs of either 4 or 8 μM.
EN-7 inhibited sporulation pathway in the bacterial genus Streptomyces.
| M.Wt | 384.395 | |
| Formula | C22H16N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McAuley S, et al. Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4.
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