DNDI-6510 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : DNDI-6510

DNDI-6510 ((S)-x38)

Catalog No.: PC-25261Not For Human Use, Lab Use Only.

DNDI-6510 ((S)-x38) is a non-covalent, potent SARS-CoV-2, isoquinoline-based MPro inhibitor with IC50 of 40 nM, SARS-CoV-2 EC50 of 0.17 uM (A549 cells).

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Biological Activity

DNDI-6510 ((S)-x38) is a non-covalent, potent SARS-CoV-2, isoquinoline-based MPro inhibitor with IC50 of 40 nM, SARS-CoV-2 EC50 of 0.17 uM (A549 cells).

Physicochemical Properties

M.Wt	474.95
Formula	C26H23ClN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(6-chloro-1'-(isoquinolin-4-yl)-1,2'-dioxo-1H-spiro[isoquinoline-4,3'-pyrrolidin]-2(3H)-yl)-N-methylcyclopropane-1-carboxamide

References

1. Griffen EJ, et al. bioRxiv [Preprint]. 2025 Jun 17:2025.06.16.660018.

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DNDI-6510 ((S)-x38)

Biological Activity

Physicochemical Properties

References

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