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Chemical Structure : DNDI-8219
Catalog No.: PC-63237Not For Human Use, Lab Use Only.
DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don).
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DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don); also has IC050 of 0.53 and 0.15 uM against L. inf and T. cruzi, displayes promising activity in the more stringent Leishmania infantum hamster model, with better solubility and pharmacokinetic properties, as well as minimal hERG inhibition.
| M.Wt | 345.234 | |
| Formula | C13H10F3N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thompson AM, et al. J Med Chem. 2018 Mar 22;61(6):2329-2352.
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