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Chemical Structure : DNMDP
Catalog No.: PC-62220Not For Human Use, Lab Use Only.
DNMDP is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12).
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DNMDP is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12).
Coexpression of SLFN12 with PDE3A correlates with DNMDP sensitivity, whereas depletion of SLFN12 results in decreased DNMDP sensitivity.
| M.Wt | 304.35 | |
| Formula | C15H20N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. de Waal L, et al. Nat Chem Biol. 2016 Feb;12(2):102-8.
2. Vandenberghe P, et al. Oncotarget. 2017 Jun 20;8(25):41026-41043.
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