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Chemical Structure : DO264
CAS No.: 2301866-59-9
Catalog No.: PC-35796Not For Human Use, Lab Use Only.
DO264 (DO-264) is a potent, selective, reversible and vivo-active inhibitor of ABHD12 that inhibits ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain with IC50 of 2.8 nM, blocks lyso-PS hydrolysis activities of recombinant mouse and human ABHD12 in transfected HEK293T cell lysates with IC50 of 30-90 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | $758 | In stock | |
| 100 mg | $1180 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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DO264 (DO-264) is a potent, selective, reversible and vivo-active inhibitor of ABHD12 that inhibits ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain with IC50 of 2.8 nM, blocks lyso-PS hydrolysis activities of recombinant mouse and human ABHD12 in transfected HEK293T cell lysates with IC50 of 30-90 nM.
DO264 selectively blocks >95% of ABHD12 activity without affecting the activity of other serine hydrolases in THP-1 cells at 1 uM.
DO264 elevates lyso-PS in mouse brain and primary human macrophages, inhibits ABHD12 and increases brain lyso-PS content, stimulates immune responses in vivo.
| M.Wt | 558.401 | |
| Formula | C23H20Cl2F3N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(1-(3-chloro-4-(2-chloro-4-(trifluoromethoxy)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thiourea |
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1. Ogasawara D, et al. Nat Chem Biol. 2018 Dec;14(12):1099-1108.
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