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Chemical Structure : DPH
CAS No.: 484049-04-9
Catalog No.: PC-42883Not For Human Use, Lab Use Only.
A cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $392 | In stock |
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A cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM); binds to the myristoyl binding site, also stimulates in vitro c-Abl phosphorylation; induces both pY245 (pEC50=5.6) and pY412 c-Abl phosphorylation; dose dependently induces Crk-L pY207 in KG-1 cells; the first small-molecule tool compound for c-Abl activation.
| M.Wt | 336.3198 | |
| Formula | C18H13FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-Imidazolidinedione, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]- |
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1. Yang J, et al. Chem Biol. 2011 Feb 25;18(2):177-86.
2. Cabigas EB, et al. J Cardiovasc Pharmacol Ther. 2015 Jan;20(1):93-103.
3. Grover P, et al. PLoS One. 2015 Jul 29;10(7):e0133590.
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