Catalog No.: PC-23564Not For Human Use, Lab Use Only.
DRI-C21041 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.31 uM in cell-free in vitro binding inhibition assay.
DRI-C21041 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.31 uM in cell-free in vitro binding inhibition assay.
DRI-C21041 displays no activity against TNF-R1–TNF-α interaction.
DRI-C21041concentration-dependently inhibits CD40L-induced marker expression (CD54, CD86, CD80, MHC-II) in THP cells
DRI-C21041 exhibits concentration-dependent inhibition of CD40L-induced human B-cell function with IC50 of 13.2 uM.
DRI-C21041 concentration-dependently inhibits CD40L-induced B cell proliferation.
