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Chemical Structure : DRI-C21045
CAS No.: 2101765-81-3
Catalog No.: PC-62015Not For Human Use, Lab Use Only.
DRI-C21045 is a novel small-molecule inhibitor of CD40-CD40L protein-protein interaction with IC50 of 0.17 uM in cell-based assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DRI-C21045 is a novel small-molecule inhibitor of CD40-CD40L protein-protein interaction with IC50 of 0.17 uM in cell-based assays.
DRI-C21045 shows >100-fold selectivity in the ability to inhibit the CD40 vs the TNF interaction.
DRI-C21045 demonstrates concentrationdependent inhibition of CD40L-induced activation of NF-κB in cells with IC50 of 17.1 uM, also inhibits CD40L-induced marker expression in THP cells and B cell activation.
DRI-C21045 inhibits alloantigen-induced immune response in mice model (20-60 mg/kg; s.c.; b.i.d.).
| M.Wt | 580.61 | |
| Formula | C32H24N2O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-(4'-(4-(Methoxycarbonyl)benzamido)biphenyl-4-ylcarboxamido)naphthalene-1-sulfonic acid |
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1. Chen J, et al. J Med Chem. 2017 Nov 9;60(21):8906-8922.
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