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Chemical Structure : DS-70
Catalog No.: PC-35545Not For Human Use, Lab Use Only.
DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity.
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DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity.
DS-70 prevents the adhesion of α4 integrin-expressing cells, antagonizes VCAM-1-mediated degranulation of mast cells and eosinophils and ERK 1/2 phosphorylation.
DS-70 does not inhibit cell adhesion mediated by the leukocyte integrins aLb2 and aMb2 or by the Arg-GlyAsp (RGD)-binding integrins α5β1, αVβ3, αVβ5, αVβ6 and αIIbβ3.
DS-70 dose-dependently reduces the clinical symptoms of allergic conjunctivitis, conjunctival α4 integrin expression and conjunctival levels of chemokines and cytokines in ovalbumin-sensitized guinea pigs.
| M.Wt | 438.484 | |
| Formula | C23H26N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dattoli SD, et al. Br J Pharmacol. 2018 Jul 26. doi: 10.1111/bph.14458.
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