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Chemical Structure : DS-II-73
Catalog No.: PC-21611Not For Human Use, Lab Use Only.
DS-II-73 is a selective α2/3/5-containing GABAA receptor (GABAAR) potentiator with IC50 of 320 nM, 381 nM and 435 nM for α2β3γ2 α3β3γ2 α5β3γ2.
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DS-II-73 is a selective α2/3/5-containing GABAA receptor (GABAAR) potentiator with IC50 of 320 nM, 381 nM and 435 nM for α2β3γ2 α3β3γ2 α5β3γ2.
DS-II-73 shows binding to the GABAAR with little ancillary activity.
DS-II-73 displays IC50 values for inhibition of [3H]-flunitrazepam binding with α2 < α3 < α5 < α1.
DS-II-73 shows robust and significant antiseizure effects.
| M.Wt | 406.24 | |
| Formula | C19H12BrN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dishary Sharmin, et al. ACS Chem Neurosci. 2024 Jan 4. doi: 10.1021/acschemneuro.3c00555.
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