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DS0464

Chemical Structure : DS0464

CAS No.:

DS0464 (DS-0464, DS 0464)

Catalog No.: PC-72806Not For Human Use, Lab Use Only.

DS0464 is a selective, bisubstrate competitive inhibitor SARS-CoV-2 nonstructural protein 14 (nsp14) with IC50 of 1.1 uM, also selective against 28 out of 33 RNA, DNA, and protein MTases.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DS0464 is a selective, bisubstrate competitive inhibitor SARS-CoV-2 nonstructural protein 14 (nsp14) with IC50 of 1.1 uM, also selective against 28 out of 33 RNA, DNA, and protein MTases.

Physicochemical Properties

M.Wt 473.552
Formula C21H27N7O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

NC1=NC=NC2=C1N=CN2C3O[C@H](CSCCNC(NCCC4=CC=CC=C4)=O)[C@@H](O)[C@H]3O

References

1. Kanchan Devkota, et al. SLAS Discov. 2021 Oct;26(9):1200-1211.

2. Devkota K, et al. bioRxiv. 2021 Feb 19:2021.02.19.424337.

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