DS2969b | GyrB inhibitor | Probechem Biochemicals

Chemical Structure : DS2969b

DS2969b (DS11960558)

Catalog No.: PC-62606Not For Human Use, Lab Use Only.

DS2969b (DS11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL.

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Biological Activity

DS2969b (DS11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL.
DS2969b (DS11960558) showes potent in vitro activity against C. difficile clinical isolates with MIC90 of 0.06 μg/mL, 2-, 32-, and 16-fold lower than the MIC90 of fidaxomicin, vancomycin, and metronidazole, respectively.
DS2969b (DS11960558) demonstrates excellent in vivo activity against Clostridium difficile (CDI) model.

Physicochemical Properties

M.Wt	428.936
Formula	C17H25ClN6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-5-ethyl-N-{(3S,4R)-1-[5-(2-hydroxypropan-2-yl)-1,3,4-thiadiazol-2-yl]-3-methoxypiperidin-4-yl}-1H-imidazole-2-carboxamide

References

1. Mathur T, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02157-17.

2. Vandell AG, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02537-17.

DS2969b (DS11960558)

Biological Activity

Physicochemical Properties

References

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