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DS44170716

Chemical Structure : DS44170716

CAS No.: 486993-62-8

DS44170716 (DS-44170716;DS 44170716)

Catalog No.: PC-60363Not For Human Use, Lab Use Only.

A novel MPT (mitochondrial permeability transition) inhibitor of that inhibits Ca2+-induced MPT in rat liver isolated mitochondria.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel MPT (mitochondrial permeability transition) inhibitor of that inhibits Ca2+-induced MPT in rat liver isolated mitochondria; protects human liver HepG2 cells from Ca2+-induced death with a level of protection similar to cyclosporin A, potently inhibits mitochondrial complex III activities and weakly inhibits complex IV and V activities.

Physicochemical Properties

M.Wt 384.273
Formula C20H18BrNO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3aS,4R,9bR)-8-bromo-4-(p-tolyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-6-carboxylic acid

References

1. Kon N, et al. Sci Rep. 2017 Jun 20;7(1):3864.

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