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DS88790512

Chemical Structure : DS88790512

CAS No.: 2231089-95-3

DS88790512 (DS 88790512;DS-88790512)

Catalog No.: PC-35044Not For Human Use, Lab Use Only.

DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM).

    Physicochemical Properties

    M.Wt 367.493
    Formula C22H29N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(((1R,3aR,7aS)-2-((R)-3-aminopiperidin-1-yl)-7a-methyl-5-oxooctahydro-1H-inden-1-yl)oxy)benzonitrile

    References

    1. Motoyama K, et al. Bioorg Med Chem Lett. 2018 Mar 22. pii: S0960-894X(18)30251-8.

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