Chemical Structure : DSB1559
CAS No.:
2974431-67-7
DSB1559
(DSB-1559)
Catalog No.: PC-28486Not For Human Use, Lab Use Only.
DSB1559 is a potent, selective and blood-brain barrier permeable PARP1 inhibitor with IC50 of 2 nM, >2000-fold selectivity compared with PARP2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DSB1559 is a potent, selective and blood-brain barrier permeable PARP1 inhibitor with IC50 of 2 nM, >2000-fold selectivity compared with PARP2.
DSB1559 shows significant selectivity for PARP1 compared with other members of the PARP protein family.
has reduced hematological toxicity compared with AZD5305.
DSB1559 penetrates the blood-brain barrier and has desirable in vitro ADME and in vivo pharmacokinetic properties.
DSB1559 reduces viability and increases STING signaling of Brca1-deficient TNBC cells
DSB1559 demonstrates increased efficacy compared with olaparib in a murine model of Brca1-deficient TNBC.
Physicochemical Properties
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M.Wt
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427.52
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Formula
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C23H30FN5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-5-(4-(3-(5-ethyl-6-oxo-1,6-dihydropyridin-2-yl)pyrrolidin-1-yl)piperidin-1-yl)-6-fluoro-N-methylpicolinamide
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References
1. Nelson A, et al. J Immunother Cancer. 2026 Oct 7;14(10):e014578.
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