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Chemical Structure : DSM265
CAS No.: 1282041-94-4
Catalog No.: PC-60458Not For Human Use, Lab Use Only.
DSM265 is a potent, highly selective, long-duration and orally bioavailable malaria DHODH (PfDHODH) inhibitor with IC50 of 0.01 ug/mL.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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DSM265 is a potent, highly selective, long-duration and orally bioavailable malaria DHODH (PfDHODH) inhibitor with IC50 of 0.01 ug/mL.
DSM265 displays excellent selectivity versus human DHODH.
DSM265 potently kills both sensitive and drug resistant strains of the parasite with EC50 of 0.001-0.004 ug/ml.
DSM265 has favorable pharmacokinetic properties and efficacious against both blood and liver stages of P. falciparum in vivo.
| M.Wt | 415.334 | |
| Formula | C14H12F7N5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine |
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1. Coteron JM, et al. J Med Chem. 2011 Aug 11;54(15):5540-61.
2. Phillips MA, et al. Sci Transl Med. 2015 Jul 15;7(296):296ra111.
3. Kokkonda S, et al. J Med Chem. 2016 Jun 9;59(11):5416-31.
4. Phillips MA, et al. ACS Infect Dis. 2016 Dec 9;2(12):945-957.
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