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Chemical Structure : DSR-141562
CAS No.: 2007975-22-4
Catalog No.: PC-47111Not For Human Use, Lab Use Only.
DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.
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|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $788 | In stock | |
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| 100 mg | Get quote |
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DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.
DSR-141562 shows 2.2- and 9.8-fold selectivity for PDE1B over PDE1A and PDE1C, but has no effect or only weak inhibitory effects for other PDE families (PDE2A, IC50=2480 nM).
DSR-141562 elevated the tissue level of cGMP in mouse striatum and frontal cortex, as well as cGMP level in the monkey CSF.
DSR-141562 demonstrated efficacy in animal models for schizophrenia, DSR-141562 (3–30 mg/kg) inhibited methamphetamine-induced locomotor hyperactivity in rats.
| M.Wt | 414.429 | |
| Formula | C19H25F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-methyl-7-(tetrahydro-2H-pyran-4-yl)-2-{[trans-4-(trifluoromethyl)cyclohexyl]-methoxy}imidazo[5,1-f][1,2,4]triazin-4(3H)-one |
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1. Enomoto T, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):692-702.
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