Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DSR-6434
CAS No.: 1059070-10-8
Catalog No.: PC-20226Not For Human Use, Lab Use Only.
DSR-6434 (DSR6434) is a highly potent, specific TLR7 agonist with EC50 of 7.2 nM (hTLR7) and 4.6 nM (mTLR7) for stimulating reporter gene activity in HEK293 cells expressing TLR7.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DSR-6434 (DSR6434) is a highly potent, specific TLR7 agonist with EC50 of 7.2 nM (hTLR7) and 4.6 nM (mTLR7) for stimulating reporter gene activity in HEK293 cells expressing TLR7.
DSR-6434 shows no acitvity in HEK293 cells expressing the structurally similar hTLR8 or hTLR9.
DSR-6434 induces type 1 interferon and activation of T and B lymphocytes, NK and NKT cells.
DSR-6434 intravenous administration enhances the efficacy of ionizing radiation (IR) and leads to improved survival in mice bearing either CT26 or KHT tumors.
DSR-6434 in combination with IR primes an antitumor CD8+ T-cell response leading to improved survival in syngeneic models of colorectal carcinoma and fibrosarcoma.
| M.Wt | 400.49 | |
| Formula | C19H28N8O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one |
|
1. Nakamura T, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):669-72.
2. Adlard AL, et al. Int J Cancer. 2014 Aug 15;135(4):820-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
