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Chemical Structure : DY131
CAS No.: 95167-41-2
Catalog No.: PC-20414Not For Human Use, Lab Use Only.
DY131 (GSK 9089) is a selective agonist of the ERRβ/γ receptor with EC50 of 130 nM, does not affect the ERRα, ERα and β (IC50>30 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $288 | In stock | |
| 100 mg | $588 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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DY131 (GSK 9089) is a selective agonist of the ERRβ/γ receptor with EC50 of 130 nM, does not affect the ERRα, ERα and β (IC50>30 uM).
DY131 inhibits growth in a diverse panel of breast cancer cell lines, causing cell death that involves the p38 stress kinase pathway and a bimodal cell cycle arrest.
DY131 potentiate the ERRgamma-induced growth inhibition in LNCaP-ERRgamma and DU145-ERRgamma cells in a dose-dependent manner.
| M.Wt | 311.39 | |
| Formula | C18H21N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-hydroxy-benzoic acid 2-[[4-(diethylamino)phenyl]methylene]hydrazide |
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1. Zuercher WJ, et al. J Med Chem. 2005 May 5;48(9):3107-9.
2. Heckler MM, et al. Oncotarget. 2016 Jul 26;7(30):47201-47220.
3. Yu DD, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1311-3.
4. Yu S, et al. Cancer Res. 2007 May 15;67(10):4904-14.
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