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Chemical Structure : Dacinostat
CAS No.: 404951-53-7
Catalog No.: PC-49004Not For Human Use, Lab Use Only.
Dacinostat (NVP-LAQ824) is a potent histone deacetylase (HDAC) inhibitor with IC50 of 32 nM, transcriptionally activates the p21 promoter in reporter gene assays with AC50 of 0.3 uM.
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Dacinostat (NVP-LAQ824) is a potent histone deacetylase (HDAC) inhibitor with IC50 of 32 nM, transcriptionally activates the p21 promoter in reporter gene assays with AC50 of 0.3 uM.
LAQ824 (30 nM) resulted in a delayed (2 h) increase in reactive oxygen species (ROS), induction of p21(WAF1/CIP1), pRb dephosphorylation, growth arrest of cells in G(0)/G(1) phase, and differentiation in in human leukemia cells (U937 and Jurkat).
NVP-LAQ824 selectively inhibited growth of cancer cell lines at submicromolar levels after 48-72 h of exposure.
NVP-LAQ824 increased histone H3 and H4 acetylation level in cancer cell lines.
NVP-LAQ824 exhibited antitumor effects in a xenograft animal model.
| M.Wt | 379.5 | |
| Formula | C22H25N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
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1. Jin JX, et al. Cell Physiol Biochem. 2017;41(3):1255-1266.
2. Roberto R Rosato, et al. Mol Pharmacol. 2006 Jan;69(1):216-25.
3. Atadja P, et al. Cancer Res. 2004 Jan 15;64(2):689-95.
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